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Uniprot ID:  P11712
  • Protein: Cytochrome P450 2C9
  • Organism: Human (Homo sapiens)
  • Length: 490
  • Sequence:
    • MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  25
PDB ID:  pdb_00001r9o , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 26-492 (23-490), 0.97
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) L19A, W20K, R21K, Q22T, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9894
auth_asym_id A
Missing residues 38VAL-42ILE:214GLN-220SER
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00005a5i , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 26-492 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L19A, W20K, R21K, Q22T, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9894
auth_asym_id A
Missing residues 38VAL-42ILE:100PHE-101PRO:214GLN-220SER
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00005x23 , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 28-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:See Sequence details
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, A477T, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00005w0c , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 27-490 (18-489), 0.97
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) L19A, W20K, R21K, Q22T, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9894
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00007rl2 , Chain A 
Resolution 2.23 Å
Residue indices (Uniprot), coverage 28-490 (24-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine:insertion
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R150H, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00005k7k , Chain A 
Resolution 2.30 Å
Residue indices (Uniprot), coverage 26-492 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L19A, W20K, R21K, Q22T, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9894
auth_asym_id A
Missing residues 38VAL-42ILE:214GLN-220SER
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00005xxi , Chain A 
Resolution 2.30 Å
Residue indices (Uniprot), coverage 28-490 (28-490), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) V490I
Insertions None
Deletions M1-G27
Sequence identity to UniProt 0.9978
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004nz2 , Chain A 
Resolution 2.45 Å
Residue indices (Uniprot), coverage 27-490 (30-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:insertion
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00004nz2 , Chain B 
Resolution 2.45 Å
Residue indices (Uniprot), coverage 27-490 (30-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:insertion
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00005x24 , Chain A 
Resolution 2.48 Å
Residue indices (Uniprot), coverage 28-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:See Sequence details
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, I359L, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00008vz7 , Chain A 
Resolution 2.53 Å
Residue indices (Uniprot), coverage 28-490 (24-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine:insertion
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R150L, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00001og5 , Chain A 
Resolution 2.55 Å
Residue indices (Uniprot), coverage 30-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00001og5 , Chain B 
Resolution 2.55 Å
Residue indices (Uniprot), coverage 30-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id B
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00001og2 , Chain A 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00001og2 , Chain B 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R21A, Q22K, S23K, S24T, G25S, R26S, G27K, K28G, L29R, K206E, I215V, C216Y, S220P, P221A, I222L, I223L
Insertions 490insHHHH
Deletions D2-W20
Sequence identity to UniProt 0.9660
auth_asym_id B
label_asym_ids of heme D
Available structure PDB
PDB ID:  pdb_00005a5j , Chain A 
Resolution 2.90 Å
Residue indices (Uniprot), coverage 26-492 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L19A, W20K, R21K, Q22T, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9894
auth_asym_id A
Missing residues 38VAL-42ILE:214GLN-220SER
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00008vx0 , Chain A 
Resolution 3.05 Å
Residue indices (Uniprot), coverage 28-491 (24-490), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine:insertion
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R125H, V490H
Insertions 489insI
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00006vlt , Chain A 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id A
Missing residues 137GLY-138LYS
Structural gaps Exists
label_asym_ids of heme I
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00006vlt , Chain B 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-491 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id B
Missing residues 135GLY-137GLY
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00006vlt , Chain C 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-491 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id C
Missing residues 135GLY-138LYS
Structural gaps Exists
label_asym_ids of heme M
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00006vlt , Chain D 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-491 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id D
Missing residues 136MET-138LYS
Structural gaps Exists
label_asym_ids of heme O
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00006vlt , Chain E 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-491 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id E
Missing residues 135GLY-138LYS
Structural gaps Exists
label_asym_ids of heme R
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00006vlt , Chain F 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-491 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id F
Missing residues 135GLY-138LYS
Structural gaps Exists
label_asym_ids of heme W
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00006vlt , Chain G 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id G
Missing residues 135GLY-135GLY
Structural gaps Exists
label_asym_ids of heme BA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00006vlt , Chain H 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 28-490 (19-490), 0.96
Difference from Uniprot sequence engineered mutation:initiating methionine:SEE SEQUENCE DETAILS
Mutations (UniProt numbering) W20A, R21K, Q22K, S23T, R144C, V490H
Insertions 489insIHHH
Deletions D2-L19
Sequence identity to UniProt 0.9873
auth_asym_id H
Missing residues 135GLY-138LYS
Structural gaps Exists
label_asym_ids of heme GA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å