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Uniprot ID:  P20815
  • Protein: Cytochrome P450 3A5
  • Organism: Human (Homo sapiens)
  • Length: 502
  • Sequence:
    • MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  28
PDB ID:  pdb_00006mjm , Chain A 
Resolution 2.20 Å
Residue indices (Uniprot), coverage 26-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id A
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00009ms2 , Chain A 
Resolution 2.25 Å
Residue indices (Uniprot), coverage 22-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id A
Missing residues 263ASP-266LYS:282LYS-287HIS
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00009ms2 , Chain B 
Resolution 2.25 Å
Residue indices (Uniprot), coverage 28-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id B
Missing residues 263ASP-267HIS:281SER-287HIS
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00007sv2 , Chain A 
Resolution 2.46 Å
Residue indices (Uniprot), coverage 23-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id A
Missing residues 282LYS-289ALA
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å
PDB ID:  pdb_00007sv2 , Chain B 
Resolution 2.46 Å
Residue indices (Uniprot), coverage 23-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id B
Missing residues 279GLN-287HIS
Structural gaps Exists
label_asym_ids of heme H
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å
PDB ID:  pdb_00007sv2 , Chain C 
Resolution 2.46 Å
Residue indices (Uniprot), coverage 29-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id C
Missing residues 262ASN-269LEU:284THR-287HIS
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00007sv2 , Chain D 
Resolution 2.46 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id D
Missing residues 194ASP-206SER:260ARG-269LEU:279GLN-286SER
Structural gaps Exists
label_asym_ids of heme N
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00007lad , Chain A 
Resolution 2.65 Å
Residue indices (Uniprot), coverage 27-496 (23-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) L499H, S500H, G501H, E502H
Insertions None
Deletions L3-L22, T498
Sequence identity to UniProt 0.9917
auth_asym_id A
Missing residues 258LYS-268ARG:279GLN-290LEU
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00008sg5 , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 23-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id A
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme I
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00008sg5 , Chain B 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 23-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id B
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme N
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00008sg5 , Chain C 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id C
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme S
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00008sg5 , Chain D 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 26-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id D
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme X
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00008sg5 , Chain E 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 27-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id E
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme CA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00008sg5 , Chain F 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 27-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id F
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme HA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008sg5 , Chain G 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 30-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id G
Missing residues 260ARG-269LEU:280ASN-287HIS
Structural gaps Exists
label_asym_ids of heme MA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00008sg5 , Chain H 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 26-496 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id H
Missing residues 260ARG-269LEU:280ASN-287HIS:419PHE-425SER
Structural gaps Exists
label_asym_ids of heme RA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005veu , Chain A 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id A
Missing residues 282LYS-288LYS
Structural gaps Exists
label_asym_ids of heme M
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00005veu , Chain B 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id B
Missing residues 282LYS-288LYS:421LYS-424ASP
Structural gaps Exists
label_asym_ids of heme O
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00005veu , Chain C 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id C
label_asym_ids of heme Q
Available structure PDB
PDB ID:  pdb_00005veu , Chain D 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id D
Missing residues 282LYS-288LYS:421LYS-423LYS
Structural gaps Exists
label_asym_ids of heme R
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005veu , Chain E 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-490 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id E
Missing residues 166LYS-168LYS:263ASP-268ARG:280ASN-288LYS:421LYS-425SER
Structural gaps Exists
label_asym_ids of heme S
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00005veu , Chain F 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 29-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id F
Missing residues 282LYS-288LYS:421LYS-424ASP
Structural gaps Exists
label_asym_ids of heme T
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005veu , Chain G 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id G
Missing residues 265GLN-267HIS:282LYS-288LYS:421LYS-424ASP
Structural gaps Exists
label_asym_ids of heme U
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00005veu , Chain H 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id H
Missing residues 282LYS-288LYS:421LYS-423LYS
Structural gaps Exists
label_asym_ids of heme V
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005veu , Chain I 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id I
Missing residues 421LYS-425SER
Structural gaps Exists
label_asym_ids of heme X
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00005veu , Chain J 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id J
Missing residues 282LYS-288LYS:421LYS-424ASP
Structural gaps Exists
label_asym_ids of heme Y
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005veu , Chain K 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-495 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id K
Missing residues 281SER-288LYS:421LYS-423LYS
Structural gaps Exists
label_asym_ids of heme Z
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00005veu , Chain L 
Resolution 2.91 Å
Residue indices (Uniprot), coverage 27-494 (24-497), 0.96
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, L499H, S500H, G501H, E502H
Insertions None
Deletions D2-L22, T498
Sequence identity to UniProt 0.9896
auth_asym_id L
Missing residues 263ASP-270ASP:282LYS-288LYS:421LYS-425SER
Structural gaps Exists
label_asym_ids of heme AA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å