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Uniprot ID:  P24462
  • Protein: Cytochrome P450 3A7
  • Organism: Human (Homo sapiens)
  • Length: 503
  • Sequence:
    • MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  14
PDB ID:  pdb_00007mk8 , Chain A 
Resolution 2.15 Å
Residue indices (Uniprot), coverage 25-497 (23-499), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) R69G, C77G, K244E, K421A, K422A, K424A, V500H, S501H, G502H, A503H
Insertions 499insFVDMEPIHMDFLRSLAFQGPHLCFFWELLCPTIRSR
Deletions L3-L22
Sequence identity to UniProt 0.9793
auth_asym_id A
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00007mk8 , Chain B 
Resolution 2.15 Å
Residue indices (Uniprot), coverage 25-497 (23-499), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) R69G, C77G, K244E, K421A, K422A, K424A, V500H, S501H, G502H, A503H
Insertions 499insFVDMEPIHMDFLRSLAFQGPHLCFFWELLCPTIRSR
Deletions L3-L22
Sequence identity to UniProt 0.9793
auth_asym_id B
Missing residues 263GLU-267HIS:281SER-283ASP
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008gk3 , Chain A 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id A
label_asym_ids of heme M
Available structure PDB
PDB ID:  pdb_00008gk3 , Chain B 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id B
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme P
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00008gk3 , Chain C 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 29-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id C
Missing residues 263GLU-268ARG
Structural gaps Exists
label_asym_ids of heme S
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008gk3 , Chain D 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 28-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id D
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme X
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00008gk3 , Chain E 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 29-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id E
Missing residues 263GLU-268ARG:282LYS-284SER
Structural gaps Exists
label_asym_ids of heme DA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008gk3 , Chain F 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-496 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id F
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme IA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008gk3 , Chain G 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id G
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme JA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00008gk3 , Chain H 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 29-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id H
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme KA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00008gk3 , Chain I 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 29-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id I
Missing residues 263GLU-268ARG
Structural gaps Exists
label_asym_ids of heme OA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00008gk3 , Chain J 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 29-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id J
Missing residues 263GLU-268ARG:282LYS-286THR
Structural gaps Exists
label_asym_ids of heme RA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00008gk3 , Chain K 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id K
Missing residues 263GLU-268ARG:281SER-285GLU
Structural gaps Exists
label_asym_ids of heme UA
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00008gk3 , Chain L 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 25-497 (24-503), 0.96
Difference from Uniprot sequence conflict:expression tag:initiating methionine
Mutations (UniProt numbering) Y23A, R69G, C77G, K244E, K421A, K422A, K424A
Insertions 503insHHHH
Deletions D2-L22
Sequence identity to UniProt 0.9855
auth_asym_id L
Structural gaps Exists
label_asym_ids of heme VA
Available structure PDB