Danish
Uniprot ID:  Q16850
  • Protein: Lanosterol 14-alpha demethylase
  • Organism: Human (Homo sapiens)
  • Length: 509
  • Sequence:
    • MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  27
PDB ID:  pdb_00006uez , Chain A 
Resolution 1.98 Å
Residue indices (Uniprot), coverage 57-502 (67-509), 0.89
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions None
Deletions A3-L57
Sequence identity to UniProt 0.9780
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00006uez , Chain B 
Resolution 1.98 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.89
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions None
Deletions A3-L57
Sequence identity to UniProt 0.9780
auth_asym_id B
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004uhi , Chain A 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 61-502 (67-509), 0.87
Mutations (UniProt numbering) None
Insertions None
Deletions M1-S66
Sequence identity to UniProt 1.0000
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004uhi , Chain B 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 61-502 (67-509), 0.87
Mutations (UniProt numbering) None
Insertions None
Deletions M1-S66
Sequence identity to UniProt 1.0000
auth_asym_id B
label_asym_ids of heme H
Available structure PDB
PDB ID:  pdb_00004uhi , Chain C 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 61-502 (67-509), 0.87
Mutations (UniProt numbering) None
Insertions None
Deletions M1-S66
Sequence identity to UniProt 1.0000
auth_asym_id C
label_asym_ids of heme K
Available structure PDB
PDB ID:  pdb_00004uhi , Chain D 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 61-502 (67-509), 0.87
Mutations (UniProt numbering) None
Insertions None
Deletions M1-S66
Sequence identity to UniProt 1.0000
auth_asym_id D
label_asym_ids of heme N
Available structure PDB
PDB ID:  pdb_00008ss0 , Chain A 
Resolution 2.25 Å
Residue indices (Uniprot), coverage 57-502 (67-509), 0.89
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions 509insHHHH
Deletions A3-L57
Sequence identity to UniProt 0.9780
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00008ss0 , Chain B 
Resolution 2.25 Å
Residue indices (Uniprot), coverage 57-502 (67-509), 0.89
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions 509insHHHH
Deletions A3-L57
Sequence identity to UniProt 0.9780
auth_asym_id B
Missing residues 271ARG-275GLN
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00004uhl , Chain A 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id A
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00004uhl , Chain B 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id B
label_asym_ids of heme L
Available structure PDB
PDB ID:  pdb_00004uhl , Chain C 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id C
label_asym_ids of heme O
Available structure PDB
PDB ID:  pdb_00004uhl , Chain D 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id D
label_asym_ids of heme R
Available structure PDB
PDB ID:  pdb_00004uhl , Chain E 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id E
label_asym_ids of heme U
Available structure PDB
PDB ID:  pdb_00004uhl , Chain F 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id F
label_asym_ids of heme X
Available structure PDB
PDB ID:  pdb_00004uhl , Chain G 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id G
label_asym_ids of heme AA
Available structure PDB
PDB ID:  pdb_00004uhl , Chain H 
Resolution 2.50 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id H
label_asym_ids of heme DA
Available structure PDB
PDB ID:  pdb_00008sbi , Chain A 
Resolution 2.73 Å
Residue indices (Uniprot), coverage 58-502 (67-508), 0.89
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions None
Deletions A3-L57, K509
Sequence identity to UniProt 0.9779
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00008sbi , Chain B 
Resolution 2.73 Å
Residue indices (Uniprot), coverage 58-502 (67-508), 0.89
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L, D237A, H320A
Insertions None
Deletions A3-L57, K509
Sequence identity to UniProt 0.9779
auth_asym_id B
label_asym_ids of heme D
Available structure PDB
PDB ID:  pdb_00003ld6 , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 58-502 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00003ld6 , Chain B 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 58-501 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00006q2t , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 58-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00006q2t , Chain B 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 59-502 (67-509), 0.88
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) V64G, S66L
Insertions None
Deletions M1-G63
Sequence identity to UniProt 0.9955
auth_asym_id B
label_asym_ids of heme N
Available structure PDB
PDB ID:  pdb_00003jus , Chain A 
Resolution 2.90 Å
Residue indices (Uniprot), coverage 58-502 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id A
label_asym_ids of heme F
Available structure PDB
PDB ID:  pdb_00003jus , Chain B 
Resolution 2.90 Å
Residue indices (Uniprot), coverage 58-502 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id B
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00003juv , Chain A 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 55-502 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00003juv , Chain A-1 
Resolution 3.12 Å
Residue indices (Uniprot), coverage 55-502 (60-508), 0.89
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) L57K, V58K, Q59T, K509H
Insertions 508insTHHHHH
Deletions A3-H56
Sequence identity to UniProt 0.9912
auth_asym_id A
label_asym_ids of heme C-1
Available structure PDB
PDB ID:  pdb_00008yqo , Chain A 
Residue indices (Uniprot), coverage 58-502 (67-509), 0.89
Difference from Uniprot sequence expression tag:initiating methionine
Mutations (UniProt numbering) V58K, Q59K, L60T, P61S, A62S, G63K, V64G, S66L
Insertions 509insHHHH
Deletions A3-L57
Sequence identity to UniProt 0.9824
auth_asym_id A
label_asym_ids of heme B
Available structure PDB