Uniprot ID: A6ZSR0
- Protein: sterol 14alpha-demethylase
- Organism: Baker's yeast (Saccharomyces cerevisiae (strain YJM789))
- Length: 530
- Sequence:
MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRNPEQKI
Number of chains: 28
| Resolution | 1.98 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-533 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G73E |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.00 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-534 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.00 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | T322I |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.02 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140F |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.05 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-533 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.05 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140F |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.10 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-535 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G73W |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.10 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (7-530), 0.99 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRH |
| Deletions | M1-S6 |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.11 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-535 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.15 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G73W |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.15 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-535 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G464S |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.20 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-535 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140F |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.20 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-533 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140H |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.20 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G73R |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.20 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (7-530), 0.99 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRH |
| Deletions | M1-S6 |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.20 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-534 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.24 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G464S |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.25 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | G73E |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| Missing residues | 438SER-441VAL |
| Structural gaps | Exists |
| label_asym_ids of heme | B |
| Available structure | PDB and Modeled |
| RMSD of experimental residues after energy minimization | 0.10 Å |
| Resolution | 2.26 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-535 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.30 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140F |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.30 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | Y140H |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.35 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | T322I |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.35 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | engineered mutation:expression tag |
| Mutations (UniProt numbering) | T322I |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.40 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.54 Å |
|---|---|
| Residue indices (Uniprot), coverage | 6-534 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.60 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-532 (1-530), 1.00 |
| Difference from Uniprot sequence | expression tag |
| Mutations (UniProt numbering) | None |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 1.0000 |
| auth_asym_id | A |
| label_asym_ids of heme | B |
| Available structure | PDB |
| Resolution | 2.65 Å |
|---|---|
| Residue indices (Uniprot), coverage | 8-535 (1-530), 1.00 |
| Difference from Uniprot sequence | conflict:expression tag |
| Mutations (UniProt numbering) | V399A |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | A |
| label_asym_ids of heme | C |
| Available structure | PDB |
| Resolution | 2.65 Å |
|---|---|
| Residue indices (Uniprot), coverage | 7-534 (1-530), 1.00 |
| Difference from Uniprot sequence | conflict:expression tag |
| Mutations (UniProt numbering) | V399A |
| Insertions | 530insGGRHHHHHH |
| Deletions | None |
| Sequence identity to UniProt | 0.9981 |
| auth_asym_id | B |
| label_asym_ids of heme | E |
| Available structure | PDB |
