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Uniprot ID:  P20813
  • Protein: Cytochrome P450 2B6
  • Organism: Human (Homo sapiens)
  • Length: 491
  • Sequence:
    • MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  28
PDB ID:  pdb_00005ufg , Chain A 
Resolution 1.76 Å
Residue indices (Uniprot), coverage 29-492 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, I114V, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9746
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00005uda , Chain A 
Resolution 1.93 Å
Residue indices (Uniprot), coverage 28-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
Missing residues 137MET-139LYS
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00005uda , Chain B 
Resolution 1.93 Å
Residue indices (Uniprot), coverage 28-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 135PHE-138GLY
Structural gaps Exists
label_asym_ids of heme H
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00003ibd , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 28-492 (30-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00004i91 , Chain A 
Resolution 2.00 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00005uap , Chain A 
Resolution 2.03 Å
Residue indices (Uniprot), coverage 28-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00005uap , Chain B 
Resolution 2.03 Å
Residue indices (Uniprot), coverage 29-492 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 136GLY-136GLY
Structural gaps Exists
label_asym_ids of heme H
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00003qoa , Chain A 
Resolution 2.10 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
Missing residues 135PHE-139LYS
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004rql , Chain A 
Resolution 2.11 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00004rql , Chain B 
Resolution 2.11 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00004rrt , Chain A 
Resolution 2.20 Å
Residue indices (Uniprot), coverage 28-491 (20-491), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
Missing residues 136GLY-138GLY
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004rrt , Chain B 
Resolution 2.20 Å
Residue indices (Uniprot), coverage 28-491 (20-491), 0.96
Difference from Uniprot sequence deletion:engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 136GLY-138GLY
Structural gaps Exists
label_asym_ids of heme J
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00004zv8 , Chain A 
Resolution 2.24 Å
Residue indices (Uniprot), coverage 28-492 (30-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, Y244W, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9746
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00005uec , Chain A 
Resolution 2.27 Å
Residue indices (Uniprot), coverage 28-492 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme B
Available structure PDB
PDB ID:  pdb_00003qu8 , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
Missing residues 138GLY-140ARG
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00003qu8 , Chain B 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 135PHE-140ARG
Structural gaps Exists
label_asym_ids of heme J
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00003qu8 , Chain C 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id C
Missing residues 135PHE-137MET:376SER-376SER
Structural gaps Exists
label_asym_ids of heme N
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00003qu8 , Chain D 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-491 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id D
Missing residues 135PHE-140ARG
Structural gaps Exists
label_asym_ids of heme Q
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00003qu8 , Chain E 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id E
Missing residues 135PHE-140ARG
Structural gaps Exists
label_asym_ids of heme U
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00003qu8 , Chain F 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-486 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id F
Missing residues 135PHE-140ARG
Structural gaps Exists
label_asym_ids of heme X
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00003ua5 , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
label_asym_ids of heme C
Available structure PDB
PDB ID:  pdb_00003ua5 , Chain B 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 29-492 (20-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 280HIS-281SER
Structural gaps Exists
label_asym_ids of heme F
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00005wbg , Chain A 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 28-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id A
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005wbg , Chain B 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 27-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id B
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme J
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005wbg , Chain C 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 27-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id C
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme M
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005wbg , Chain D 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 27-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id D
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme P
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005wbg , Chain E 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 28-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id E
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme S
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005wbg , Chain F 
Resolution 2.99 Å
Residue indices (Uniprot), coverage 27-491 (21-491), 0.96
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) Q21A, R22K, H23K, P24T, N25S, T26S, H27K, D28G, R29K, Y226H, K262R
Insertions 491insHHHH
Deletions E2-V20
Sequence identity to UniProt 0.9767
auth_asym_id F
Missing residues 278ASN-278ASN
Structural gaps Exists
label_asym_ids of heme V
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å