Danish
Uniprot ID:  P33261
  • Protein: Cytochrome P450 2C19
  • Organism: Human (Homo sapiens)
  • Length: 490
  • Sequence:
    • MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  4
PDB ID:  pdb_00004gqs , Chain A 
Resolution 2.87 Å
Residue indices (Uniprot), coverage 29-492 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) I19A, W20K, R21K, Q22T, I331V, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9873
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004gqs , Chain B 
Resolution 2.87 Å
Residue indices (Uniprot), coverage 29-490 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) I19A, W20K, R21K, Q22T, I331V, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9873
auth_asym_id B
Missing residues 219PHE-224ASP
Structural gaps Exists
label_asym_ids of heme J
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00004gqs , Chain C 
Resolution 2.87 Å
Residue indices (Uniprot), coverage 29-490 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) I19A, W20K, R21K, Q22T, I331V, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9873
auth_asym_id C
label_asym_ids of heme L
Available structure PDB
PDB ID:  pdb_00004gqs , Chain D 
Resolution 2.87 Å
Residue indices (Uniprot), coverage 29-490 (23-489), 0.97
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) I19A, W20K, R21K, Q22T, I331V, V490H
Insertions 489insIHHH
Deletions D2-S18
Sequence identity to UniProt 0.9873
auth_asym_id D
Missing residues 132ARG-141ILE
Structural gaps Exists
label_asym_ids of heme N
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.21 Å