Danish
Uniprot ID:  Q385E8
  • Protein: Lanosterol 14-alpha-demethylase
  • Organism: Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
  • Length: 481
  • Sequence:
    • MLLEVAIFLLTALALYSFYFVKSFNVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRKAAAA
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  33
PDB ID:  pdb_00004g3j , Chain A 
Resolution 1.83 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004g3j , Chain B 
Resolution 1.83 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00004g3j , Chain C 
Resolution 1.83 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00004g3j , Chain D 
Resolution 1.83 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id D
label_asym_ids of heme K
Available structure PDB
PDB ID:  pdb_00003gw9 , Chain A 
Resolution 1.87 Å
Residue indices (Uniprot), coverage 28-477 (28-477), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27, A478-A481
Sequence identity to UniProt 0.9911
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00003gw9 , Chain B 
Resolution 1.87 Å
Residue indices (Uniprot), coverage 29-477 (28-477), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27, A478-A481
Sequence identity to UniProt 0.9911
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00003gw9 , Chain C 
Resolution 1.87 Å
Residue indices (Uniprot), coverage 29-477 (28-477), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27, A478-A481
Sequence identity to UniProt 0.9911
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00003gw9 , Chain D 
Resolution 1.87 Å
Residue indices (Uniprot), coverage 29-477 (28-477), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27, A478-A481
Sequence identity to UniProt 0.9911
auth_asym_id D
label_asym_ids of heme K
Available structure PDB
PDB ID:  pdb_00003g1q , Chain A 
Resolution 1.89 Å
Residue indices (Uniprot), coverage 29-476 (27-476), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) T27S, R28K, P29G, T30K, D31L
Insertions None
Deletions M1-V26, K477-A481
Sequence identity to UniProt 0.9889
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00003g1q , Chain B 
Resolution 1.89 Å
Residue indices (Uniprot), coverage 29-476 (27-476), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) T27S, R28K, P29G, T30K, D31L
Insertions None
Deletions M1-V26, K477-A481
Sequence identity to UniProt 0.9889
auth_asym_id B
Missing residues 253ASN-256SER
Structural gaps Exists
label_asym_ids of heme F
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å
PDB ID:  pdb_00003g1q , Chain C 
Resolution 1.89 Å
Residue indices (Uniprot), coverage 27-476 (27-476), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) T27S, R28K, P29G, T30K, D31L
Insertions None
Deletions M1-V26, K477-A481
Sequence identity to UniProt 0.9889
auth_asym_id C
Missing residues 255ASP-257SER
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00003g1q , Chain D 
Resolution 1.89 Å
Residue indices (Uniprot), coverage 29-476 (27-476), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) T27S, R28K, P29G, T30K, D31L
Insertions None
Deletions M1-V26, K477-A481
Sequence identity to UniProt 0.9889
auth_asym_id D
label_asym_ids of heme H
Available structure PDB
PDB ID:  pdb_00003tik , Chain A 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00003tik , Chain B 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00003tik , Chain C 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00003tik , Chain D 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28K, P29G, T30K, D31L
Insertions None
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id D
label_asym_ids of heme K
Available structure PDB
PDB ID:  pdb_00004g7g , Chain A 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004g7g , Chain B 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00004g7g , Chain C 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00004g7g , Chain D 
Resolution 2.05 Å
Residue indices (Uniprot), coverage 29-476 (29-476), 0.93
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31, K477-A481
Sequence identity to UniProt 0.9955
auth_asym_id D
label_asym_ids of heme K
Available structure PDB
PDB ID:  pdb_00002x2n , Chain A 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-478 (22-481), 0.97
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) Y16A, S17K, F18K, Y19K, F20K, V21K, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-L15
Sequence identity to UniProt 0.9807
auth_asym_id A
Missing residues 255ASP-255ASP
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.11 Å
PDB ID:  pdb_00002x2n , Chain B 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-477 (22-481), 0.97
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) Y16A, S17K, F18K, Y19K, F20K, V21K, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-L15
Sequence identity to UniProt 0.9807
auth_asym_id B
Missing residues 253ASN-256SER
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å
PDB ID:  pdb_00002x2n , Chain C 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-477 (22-481), 0.97
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) Y16A, S17K, F18K, Y19K, F20K, V21K, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-L15
Sequence identity to UniProt 0.9807
auth_asym_id C
Missing residues 251ALA-257SER
Structural gaps Exists
label_asym_ids of heme I
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00002x2n , Chain D 
Resolution 2.60 Å
Residue indices (Uniprot), coverage 30-477 (22-481), 0.97
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) Y16A, S17K, F18K, Y19K, F20K, V21K, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-L15
Sequence identity to UniProt 0.9807
auth_asym_id D
Missing residues 255ASP-255ASP
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004bjk , Chain A 
Resolution 2.67 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, V26S, T27S, R28K, P29G, T30K, D31L, V34M, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-V21
Sequence identity to UniProt 0.9696
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00004bjk , Chain B 
Resolution 2.67 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, V26S, T27S, R28K, P29G, T30K, D31L, V34M, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-V21
Sequence identity to UniProt 0.9696
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00004bjk , Chain C 
Resolution 2.67 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, V26S, T27S, R28K, P29G, T30K, D31L, V34M, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-V21
Sequence identity to UniProt 0.9696
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00004bjk , Chain D 
Resolution 2.67 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, V26S, T27S, R28K, P29G, T30K, D31L, V34M, E249A, E250A, E251A
Insertions 481insHHHHHHHH
Deletions L2-V21
Sequence identity to UniProt 0.9696
auth_asym_id D
Missing residues 251ALA-256SER
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.17 Å
PDB ID:  pdb_00002wv2 , Chain A 
Resolution 2.70 Å
Residue indices (Uniprot), coverage 30-477 (22-481), 0.97
Mutations (UniProt numbering) Y16A, S17K, F18K, Y19K, F20K, V21K
Insertions 481insHHHHHHHH
Deletions L2-L15
Sequence identity to UniProt 0.9872
auth_asym_id A
Missing residues 253ASN-257SER
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00003p99 , Chain A 
Resolution 3.00 Å
Residue indices (Uniprot), coverage 29-476 (29-481), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31
Sequence identity to UniProt 0.9956
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00003p99 , Chain B 
Resolution 3.00 Å
Residue indices (Uniprot), coverage 29-476 (29-481), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31
Sequence identity to UniProt 0.9956
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00003p99 , Chain C 
Resolution 3.00 Å
Residue indices (Uniprot), coverage 29-476 (29-481), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31
Sequence identity to UniProt 0.9956
auth_asym_id C
Missing residues 253ASN-256SER
Structural gaps Exists
label_asym_ids of heme I
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00003p99 , Chain D 
Resolution 3.00 Å
Residue indices (Uniprot), coverage 29-476 (29-481), 0.94
Difference from Uniprot sequence engineered mutation
Mutations (UniProt numbering) M1G, L2K
Insertions None
Deletions E4-D31
Sequence identity to UniProt 0.9956
auth_asym_id D
label_asym_ids of heme K
Available structure PDB