Danish
Uniprot ID:  Q7Z1V1
  • Protein: Sterol 14-alpha demethylase
  • Organism: Trypanosoma cruzi (strain CL Brener)
  • Length: 481
  • Sequence:
    • MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPTLNQCLVKYTRKKKLPS
Exclude chains with
Mutations (vs. UniProt)
Clear
Number of chains:  39
PDB ID:  pdb_00004c27 , Chain A 
Resolution 1.95 Å
Residue indices (Uniprot), coverage 29-478 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9848
auth_asym_id A
Missing residues 252ALA-257ASN
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004c27 , Chain B 
Resolution 1.95 Å
Residue indices (Uniprot), coverage 30-478 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9848
auth_asym_id B
Missing residues 252ALA-257ASN
Structural gaps Exists
label_asym_ids of heme H
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004c28 , Chain A 
Resolution 2.03 Å
Residue indices (Uniprot), coverage 29-477 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9848
auth_asym_id A
Missing residues 252ALA-257ASN
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004c28 , Chain B 
Resolution 2.03 Å
Residue indices (Uniprot), coverage 29-476 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9848
auth_asym_id B
Missing residues 252ALA-258THR
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004c0c , Chain A 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 254LYS-257ASN
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004c0c , Chain A-1 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 254LYS-257ASN
Structural gaps Exists
label_asym_ids of heme B-1
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004c0c , Chain A-2 
Resolution 2.04 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 254LYS-257ASN
Structural gaps Exists
label_asym_ids of heme B-2
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004coh , Chain A 
Resolution 2.08 Å
Residue indices (Uniprot), coverage 30-478 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) Y19A, S20K, V21K, K22T, F24S, N25K, T26G, T27K, R28L
Insertions 481insHHHHHH
Deletions F2-V18
Sequence identity to UniProt 0.9806
auth_asym_id A
Missing residues 251GLU-257ASN
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.10 Å
PDB ID:  pdb_00004coh , Chain B 
Resolution 2.08 Å
Residue indices (Uniprot), coverage 29-480 (29-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) Y19A, S20K, V21K, K22T, F24S, N25K, T26G, T27K, R28L
Insertions 481insHHHHHH
Deletions F2-V18
Sequence identity to UniProt 0.9806
auth_asym_id B
Missing residues 251GLU-257ASN
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00002wx2 , Chain A 
Resolution 2.27 Å
Residue indices (Uniprot), coverage 26-477 (22-481), 0.97
Mutations (UniProt numbering) Y16A, S17K, V18K, Y19K, S20K, V21K
Insertions 481insHHHHHH
Deletions F2-L15
Sequence identity to UniProt 0.9872
auth_asym_id A
Missing residues 225GLN-227ALA:251GLU-258THR
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00002wx2 , Chain B 
Resolution 2.27 Å
Residue indices (Uniprot), coverage 28-485 (22-481), 0.97
Mutations (UniProt numbering) Y16A, S17K, V18K, Y19K, S20K, V21K
Insertions 481insHHHHHH
Deletions F2-L15
Sequence identity to UniProt 0.9872
auth_asym_id B
Missing residues 202SER-206SER:250GLU-258THR
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00002wuz , Chain A 
Resolution 2.35 Å
Residue indices (Uniprot), coverage 27-476 (22-481), 0.97
Mutations (UniProt numbering) Y16A, S17K, V18K, Y19K, S20K, V21K
Insertions 481insHHHHHH
Deletions F2-L15
Sequence identity to UniProt 0.9872
auth_asym_id A
Missing residues 251GLU-256ASN
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00002wuz , Chain B 
Resolution 2.35 Å
Residue indices (Uniprot), coverage 28-480 (22-481), 0.97
Mutations (UniProt numbering) Y16A, S17K, V18K, Y19K, S20K, V21K
Insertions 481insHHHHHH
Deletions F2-L15
Sequence identity to UniProt 0.9872
auth_asym_id B
Missing residues 251GLU-259SER
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004uqh , Chain A 
Resolution 2.43 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 251GLU-257ASN
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004uqh , Chain A-1 
Resolution 2.43 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 251GLU-257ASN
Structural gaps Exists
label_asym_ids of heme B-1
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004uqh , Chain A-2 
Resolution 2.43 Å
Residue indices (Uniprot), coverage 28-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 251GLU-257ASN
Structural gaps Exists
label_asym_ids of heme B-2
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004uvr , Chain A 
Resolution 2.48 Å
Residue indices (Uniprot), coverage 29-476 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 250GLU-258THR
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00004uvr , Chain A-1 
Resolution 2.48 Å
Residue indices (Uniprot), coverage 29-476 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 250GLU-258THR
Structural gaps Exists
label_asym_ids of heme B-1
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.12 Å
PDB ID:  pdb_00004ck8 , Chain A 
Resolution 2.62 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 222PRO-222PRO
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.17 Å
PDB ID:  pdb_00004ck8 , Chain B 
Resolution 2.62 Å
Residue indices (Uniprot), coverage 28-478 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id B
Missing residues 222PRO-222PRO
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.20 Å
PDB ID:  pdb_00004cka , Chain A 
Resolution 2.70 Å
Residue indices (Uniprot), coverage 29-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 216PRO-222PRO:251GLU-258THR
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00004ck9 , Chain A 
Resolution 2.74 Å
Residue indices (Uniprot), coverage 29-477 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 216PRO-222PRO:251GLU-258THR
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.16 Å
PDB ID:  pdb_00005ajr , Chain A 
Resolution 2.75 Å
Residue indices (Uniprot), coverage 29-478 (32-481), 0.94
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 222PRO-222PRO
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.18 Å
PDB ID:  pdb_00003zg2 , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-478 (28-481), 0.94
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 221LEU-222PRO
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00004h6o , Chain A 
Resolution 2.80 Å
Residue indices (Uniprot), coverage 28-477 (28-481), 0.95
Difference from Uniprot sequence engineered mutation:expression tag:initiating methionine
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions F2-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 216PRO-222PRO:251GLU-258THR
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00004bmm , Chain A 
Resolution 2.84 Å
Residue indices (Uniprot), coverage 30-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 252ALA-258THR
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.18 Å
PDB ID:  pdb_00004bmm , Chain B 
Resolution 2.84 Å
Residue indices (Uniprot), coverage 30-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id B
Missing residues 252ALA-257ASN
Structural gaps Exists
label_asym_ids of heme G
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.20 Å
PDB ID:  pdb_00004bmm , Chain C 
Resolution 2.84 Å
Residue indices (Uniprot), coverage 30-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id C
Missing residues 252ALA-259SER
Structural gaps Exists
label_asym_ids of heme I
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.18 Å
PDB ID:  pdb_00004bmm , Chain D 
Resolution 2.84 Å
Residue indices (Uniprot), coverage 30-477 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id D
Missing residues 253SER-258THR
Structural gaps Exists
label_asym_ids of heme K
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.15 Å
PDB ID:  pdb_00003khm , Chain A 
Resolution 2.85 Å
Residue indices (Uniprot), coverage 24-479 (24-481), 0.95
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) M1K, F2T, I3S, E4G, A5K, I6G, V7K
Insertions 481insHHHHHH
Deletions A9-D31
Sequence identity to UniProt 0.9847
auth_asym_id A
Missing residues 212ALA-217TRP:250GLU-258THR
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.18 Å
PDB ID:  pdb_00003k1o , Chain A 
Resolution 2.89 Å
Residue indices (Uniprot), coverage 30-477 (30-481), 0.94
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) T30K, D31T
Insertions 481insHHHHHH
Deletions M1-P29
Sequence identity to UniProt 0.9956
auth_asym_id A
Missing residues 217TRP-220ARG:255ASP-256ASN
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.14 Å
PDB ID:  pdb_00003zg3 , Chain A 
Resolution 2.90 Å
Residue indices (Uniprot), coverage 29-478 (28-481), 0.94
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) R28A, P29K, T30K, D31T
Insertions 481insHHHHHH
Deletions M1-T27
Sequence identity to UniProt 0.9912
auth_asym_id A
Missing residues 218LEU-222PRO
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.13 Å
PDB ID:  pdb_00003ksw , Chain A 
Resolution 3.05 Å
Residue indices (Uniprot), coverage 30-477 (30-481), 0.94
Difference from Uniprot sequence engineered mutation:expression tag
Mutations (UniProt numbering) T30K, D31T
Insertions 481insHHHHHH
Deletions M1-P29
Sequence identity to UniProt 0.9956
auth_asym_id A
Missing residues 217TRP-220ARG
Structural gaps Exists
label_asym_ids of heme B
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.17 Å
PDB ID:  pdb_00004by0 , Chain A 
Resolution 3.10 Å
Residue indices (Uniprot), coverage 30-476 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id A
Missing residues 252ALA-257ASN
Structural gaps Exists
label_asym_ids of heme C
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.20 Å
PDB ID:  pdb_00004by0 , Chain B 
Resolution 3.10 Å
Residue indices (Uniprot), coverage 30-476 (32-481), 0.96
Difference from Uniprot sequence expression tag
Mutations (UniProt numbering) K22A, S23K, F24K, N25T, T26S, T27S, R28K, P29G, T30K, D31L
Insertions 481insHHHHHH
Deletions F2-V21
Sequence identity to UniProt 0.9783
auth_asym_id B
Missing residues 253SER-257ASN
Structural gaps Exists
label_asym_ids of heme E
Available structure PDB and Modeled
RMSD of experimental residues after energy minimization 0.26 Å
PDB ID:  pdb_00006fmo , Chain A 
Resolution 3.18 Å
Residue indices (Uniprot), coverage 31-478 (1-481), 1.00
Difference from Uniprot sequence conflict:engineered mutation:expression tag
Mutations (UniProt numbering) A9G, D31L, I105F
Insertions 481insHHHH
Deletions None
Sequence identity to UniProt 0.9938
auth_asym_id A
label_asym_ids of heme E
Available structure PDB
PDB ID:  pdb_00006fmo , Chain B 
Resolution 3.18 Å
Residue indices (Uniprot), coverage 31-478 (1-481), 1.00
Difference from Uniprot sequence conflict:engineered mutation:expression tag
Mutations (UniProt numbering) A9G, D31L, I105F
Insertions 481insHHHH
Deletions None
Sequence identity to UniProt 0.9938
auth_asym_id B
label_asym_ids of heme G
Available structure PDB
PDB ID:  pdb_00006fmo , Chain C 
Resolution 3.18 Å
Residue indices (Uniprot), coverage 31-478 (1-481), 1.00
Difference from Uniprot sequence conflict:engineered mutation:expression tag
Mutations (UniProt numbering) A9G, D31L, I105F
Insertions 481insHHHH
Deletions None
Sequence identity to UniProt 0.9938
auth_asym_id C
label_asym_ids of heme I
Available structure PDB
PDB ID:  pdb_00006fmo , Chain D 
Resolution 3.18 Å
Residue indices (Uniprot), coverage 31-478 (1-481), 1.00
Difference from Uniprot sequence conflict:engineered mutation:expression tag
Mutations (UniProt numbering) A9G, D31L, I105F
Insertions 481insHHHH
Deletions None
Sequence identity to UniProt 0.9938
auth_asym_id D
label_asym_ids of heme K
Available structure PDB